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Peptide Hormone

Search Result - 1

HMRbase accession number	10032
Swiss-prot Accession number	P47932 (Sequence in FASTA format)
Description	Prorelaxin 1 precursor [Contains: Relaxin B chain; Relaxin A chain].
Source organism	Mus musculus (Mouse)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Mus.
Subcellular location	Secreted
Developmental Stage	N/A
Similarity	Belongs to the insulin family.
Tissue Specificity	N/A
Post translational modification	N/A
Function	Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals
Protein Length	185 Amino acids
Molecular weight	20571
References	1  PubMed abstract 8452637 2  PubMed abstract 8216305
Domain Name	Insulin
Hormone Name	Relaxin B chain
Mature Hormone Sequence	RVSEEWMDGFIRMCGREYARELIKICGASVGRLAL
Position of mature hormone in Pre-Hormone protein	35 Residues from position (23-57)
Receptor	Q91ZZ5    Detail in HMRbase
Gene ID	19773
PDB ID	N/A
Drugpedia	wiki
Comments

Search Result - 2

HMRbase accession number	10034
Swiss-prot Accession number	Q9TRM8 (Sequence in FASTA format)
Description	Prorelaxin precursor [Contains: Relaxin B chain; Relaxin A chain].
Source organism	Canis familiaris (Dog)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;Canis.
Subcellular location	Secreted
Developmental Stage	N/A
Similarity	Belongs to the insulin family.
Tissue Specificity	Placenta; syncytiotrophoblast
Post translational modification	N/A
Function	Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals
Protein Length	177 Amino acids
Molecular weight	20563
References	1  PubMed abstract 10026098 2  PubMed abstract 1388669
Domain Name	Insulin
Hormone Name	Relaxin B chain
Mature Hormone Sequence	TDDKKLKACGRDYVRLQIEVCGSIWWGRKAGQLRE
Position of mature hormone in Pre-Hormone protein	35 Residues from position (26-60)
Receptor	Q5XM32    Detail in HMRbase
Gene ID	403742
PDB ID	N/A
Drugpedia	wiki
Comments

Search Result - 3

HMRbase accession number	10060
Swiss-prot Accession number	Q7M3C4 (Sequence in FASTA format)
Description	Relaxin B chain.
Source organism	Phocoenoides dalli dalli (Dall's porpoise)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Cetacea;Odontoceti; Phocoenidae; Phocoenoides.
Subcellular location	Secreted
Developmental Stage	N/A
Similarity	Belongs to the insulin family.
Tissue Specificity	N/A
Post translational modification	N/A
Function	Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals
Protein Length	31 Amino acids
Molecular weight	3538
References	1   Woods A.S., Cotter R.J., Yoshioka M., Buellesbach E., Schwabe C.; "Enzymatic digestion on the sample foil as a method for sequencedetermination by plasma desorption mass spectrometry: the primarystructure of porpoise relaxin."; Int. J. Mass Spectrom. Ion Process. 111:77-88(1991).
Domain Name	N/A
Hormone Name	Relaxin B chain
Mature Hormone Sequence	QRTNDFIKACGRELVRVWVEICGSVSWGRTA
Position of mature hormone in Pre-Hormone protein	31 Residues from position (1-31)
Receptor	N/A
Gene ID	N/A
PDB ID	N/A
Drugpedia	wiki
Comments	!Receptor for this Hormone are either unknown or have not yet been curated

Search Result - 4

HMRbase accession number	10292
Swiss-prot Accession number	Q9MYK8 (Sequence in FASTA format)
Description	Prorelaxin precursor (RXN) [Contains: Relaxin B chain; Relaxin Achain].
Source organism	Felis silvestris catus (Cat)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae;Felinae; Felis.
Subcellular location	Secreted (By similarity)
Developmental Stage	N/A
Similarity	Belongs to the insulin family.
Tissue Specificity	Expressed by the placenta. Exclusively detected in cells located in the lamellar placental labyrinth and absent from other placental and nonplacental uterine parts
Post translational modification	N/A
Function	Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals
Protein Length	180 Amino acids
Molecular weight	20360
References	1  PubMed abstract 9915995
Domain Name	Insulin
Hormone Name	Relaxin B chain
Mature Hormone Sequence	QEEVLKACGREFVRLQIRICGSLSWG
Position of mature hormone in Pre-Hormone protein	26 Residues from position (26-51)
Receptor	N/A
Gene ID	493883
PDB ID	N/A
Drugpedia	wiki
Comments	!Receptor for this Hormone are either unknown or have not yet been curated

Search Result - 5

HMRbase accession number	10294
Swiss-prot Accession number	Q64171 (Sequence in FASTA format)
Description	Prorelaxin precursor [Contains: Relaxin B chain; Relaxin A chain].
Source organism	Mesocricetus auratus (Golden hamster)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Cricetidae; Cricetinae; Mesocricetus.
Subcellular location	Secreted
Developmental Stage	N/A
Similarity	Belongs to the insulin family.
Tissue Specificity	N/A
Post translational modification	N/A
Function	Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. It bears mature young, and allows separation of the pelvic bones
Protein Length	177 Amino acids
Molecular weight	20007
References	1  PubMed abstract 7492700
Domain Name	Insulin
Hormone Name	Relaxin B chain
Mature Hormone Sequence	RVTKEWLDEVIHVCGREYVRAILDICAATVGLEAPPL
Position of mature hormone in Pre-Hormone protein	37 Residues from position (23-59)
Receptor	N/A
Gene ID	N/A
PDB ID	N/A
Drugpedia	wiki
Comments	!Receptor for this Hormone are either unknown or have not yet been curated

Search Result - 6

HMRbase accession number	11208
Swiss-prot Accession number	P51454 (Sequence in FASTA format)
Description	Prorelaxin H1 precursor [Contains: Relaxin B chain; Relaxin A chain](Fragment).
Source organism	Pan troglodytes (Chimpanzee)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Pan.
Subcellular location	Secreted
Developmental Stage	N/A
Similarity	Belongs to the insulin family.
Tissue Specificity	Expressed in the corpus luteum of pregnancy but not in the placenta
Post translational modification	N/A
Function	Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix
Protein Length	166 Amino acids
Molecular weight	18731
References	1  PubMed abstract 8182365
Domain Name	Insulin
Hormone Name	Relaxin B chain
Mature Hormone Sequence	DSWMDEVIKLCGRELVRAQIAICGMSTWS
Position of mature hormone in Pre-Hormone protein	29 Residues from position (6-34)
Receptor	N/A
Gene ID	N/A
PDB ID	N/A
Drugpedia	wiki
Comments	!Receptor for this Hormone are either unknown or have not yet been curated

Search Result - 7

HMRbase accession number	11210
Swiss-prot Accession number	P01347 (Sequence in FASTA format)
Description	Prorelaxin 1 precursor [Contains: Relaxin B chain; Relaxin A chain].
Source organism	Rattus norvegicus (Rat)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Rattus.
Subcellular location	Secreted
Developmental Stage	N/A
Similarity	Belongs to the insulin family.
Tissue Specificity	N/A
Post translational modification	N/A
Function	Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals
Protein Length	186 Amino acids
Molecular weight	20489
References	1  PubMed abstract 7231533 2  PubMed abstract 14659888 3  PubMed abstract 7004862
Domain Name	Insulin
Hormone Name	Relaxin B chain
Mature Hormone Sequence	RVSEEWMDQVIQVCGRGYARAWIEVCGASVGRLAL
Position of mature hormone in Pre-Hormone protein	35 Residues from position (23-57)
Receptor	N/A
Gene ID	25616
PDB ID	N/A
Drugpedia	wiki
Comments	!Receptor for this Hormone are either unknown or have not yet been curated

Search Result - 8

HMRbase accession number	11212
Swiss-prot Accession number	P51455 (Sequence in FASTA format)
Description	Prorelaxin H2 precursor [Contains: Relaxin B chain; Relaxin A chain](Fragment).
Source organism	Pan troglodytes (Chimpanzee)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Pan.
Subcellular location	Secreted
Developmental Stage	N/A
Similarity	Belongs to the insulin family.
Tissue Specificity	Expressed in the corpus luteum of pregnancy and in the placenta
Post translational modification	N/A
Function	Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix
Protein Length	166 Amino acids
Molecular weight	18761
References	1  PubMed abstract 8182365 2  PubMed abstract 8735594
Domain Name	Insulin
Hormone Name	Relaxin B chain
Mature Hormone Sequence	DSWMDEVIKLCGRELVRAQIAICGKSTWS
Position of mature hormone in Pre-Hormone protein	29 Residues from position (6-34)
Receptor	N/A
Gene ID	N/A
PDB ID	N/A
Drugpedia	wiki
Comments	!Receptor for this Hormone are either unknown or have not yet been curated

Search Result - 9

HMRbase accession number	11214
Swiss-prot Accession number	P11184 (Sequence in FASTA format)
Description	Relaxin [Contains: Relaxin B chain; Relaxin A chain].
Source organism	Balaenoptera acutorostrata (Minke whale) (Lesser rorqual)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Cetacea;Mysticeti; Balaenopteridae; Balaenoptera.
Subcellular location	Secreted
Developmental Stage	N/A
Similarity	Belongs to the insulin family.
Tissue Specificity	N/A
Post translational modification	N/A
Function	Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals
Protein Length	54 Amino acids
Molecular weight	6098
References	1  PubMed abstract 2910872
Domain Name	Insulin
Hormone Name	Relaxin B chain
Mature Hormone Sequence	QSTNDLIKACGRELVRLWVEICGSVRWGQSAL
Position of mature hormone in Pre-Hormone protein	32 Residues from position (1-32)
Receptor	N/A
Gene ID	N/A
PDB ID	N/A
Drugpedia	wiki
Comments	!Receptor for this Hormone are either unknown or have not yet been curated

Search Result - 10

HMRbase accession number	11216
Swiss-prot Accession number	P11185 (Sequence in FASTA format)
Description	Relaxin [Contains: Relaxin B chain; Relaxin A chain].
Source organism	Balaenoptera edeni (Pigmy Bryde's whale)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Cetacea;Mysticeti; Balaenopteridae; Balaenoptera.
Subcellular location	Secreted
Developmental Stage	N/A
Similarity	Belongs to the insulin family.
Tissue Specificity	N/A
Post translational modification	N/A
Function	Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals
Protein Length	54 Amino acids
Molecular weight	6071
References	1  PubMed abstract 2910872
Domain Name	Insulin
Hormone Name	Relaxin B chain
Mature Hormone Sequence	QSTNDLIKACGRELVRLWVEICGSVSWGRTAL
Position of mature hormone in Pre-Hormone protein	32 Residues from position (1-32)
Receptor	N/A
Gene ID	N/A
PDB ID	N/A
Drugpedia	wiki
Comments	!Receptor for this Hormone are either unknown or have not yet been curated

Search Result - 11

HMRbase accession number	11217
Swiss-prot Accession number	P22969 (Sequence in FASTA format)
Description	Prorelaxin precursor (RXN) [Contains: Relaxin B chain; Relaxin Achain].
Source organism	Equus caballus (Horse)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
Subcellular location	Secreted
Developmental Stage	N/A
Similarity	Belongs to the insulin family.
Tissue Specificity	N/A
Post translational modification	N/A
Function	Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals
Protein Length	182 Amino acids
Molecular weight	20721
References	1   Min K., Shiota K., Ogawa T.; "Molecular cloning of equine preprorelaxin cDNA."; J. Reprod. Dev. 42:171-178(1996). 2  PubMed abstract 7543295 3  PubMed abstract 2055195
Domain Name	Insulin
Hormone Name	Relaxin B chain
Mature Hormone Sequence	QKPDDVIKACGRELARLRIEICGSLSWK
Position of mature hormone in Pre-Hormone protein	28 Residues from position (26-53)
Receptor	N/A
Gene ID	100033823
PDB ID	N/A
Drugpedia	wiki
Comments	!Receptor for this Hormone are either unknown or have not yet been curated

Search Result - 12

HMRbase accession number	11219
Swiss-prot Accession number	P19884 (Sequence in FASTA format)
Description	Prorelaxin precursor [Contains: Relaxin B chain; Relaxin A chain].
Source organism	Macaca mulatta (Rhesus macaque)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
Subcellular location	Secreted
Developmental Stage	N/A
Similarity	Belongs to the insulin family.
Tissue Specificity	N/A
Post translational modification	N/A
Function	Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix
Protein Length	185 Amino acids
Molecular weight	20895
References	1  PubMed abstract 2590381
Domain Name	Insulin
Hormone Name	Relaxin B chain
Mature Hormone Sequence	AKWMDDVIKACGRELVRAQIAICGKSTLG
Position of mature hormone in Pre-Hormone protein	29 Residues from position (25-53)
Receptor	N/A
Gene ID	N/A
PDB ID	N/A
Drugpedia	wiki
Comments	!Receptor for this Hormone are either unknown or have not yet been curated

Search Result - 13

HMRbase accession number	11221
Swiss-prot Accession number	P01348 (Sequence in FASTA format)
Description	Prorelaxin precursor [Contains: Relaxin B chain; Relaxin A chain].
Source organism	Sus scrofa (Pig)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;Sus.
Subcellular location	Secreted
Developmental Stage	N/A
Similarity	Belongs to the insulin family.
Tissue Specificity	N/A
Post translational modification	N/A
Function	Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals
Protein Length	182 Amino acids
Molecular weight	20818
References	1  PubMed abstract 6897721 2  PubMed abstract 2442155 3  PubMed abstract 876374 4  PubMed abstract 851452 5  PubMed abstract 843375 6  PubMed abstract 938497 7  PubMed abstract 887933 8  PubMed abstract 622170
Domain Name	Insulin
Hormone Name	Relaxin B chain
Mature Hormone Sequence	QSTNDFIKACGRELVRLWVEICGSVSWGRTAL
Position of mature hormone in Pre-Hormone protein	32 Residues from position (25-56)
Receptor	N/A
Gene ID	396891
PDB ID	1RLX   2RLX   3RLX   4RLX
Drugpedia	wiki
Comments	!Receptor for this Hormone are either unknown or have not yet been curated

Search Result - 14

HMRbase accession number	11223
Swiss-prot Accession number	P11952 (Sequence in FASTA format)
Description	Relaxin [Contains: Relaxin B chain; Relaxin A chain].
Source organism	Raja erinacea (Little skate)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;Elasmobranchii; Squalea; Hypnosqualea; Pristiorajea; Batoidea;Rajiformes; Rajidae; Leucoraja.
Subcellular location	Secreted
Developmental Stage	N/A
Similarity	Belongs to the insulin family.
Tissue Specificity	N/A
Post translational modification	N/A
Function	N/A
Protein Length	64 Amino acids
Molecular weight	7499
References	1  PubMed abstract 3827922
Domain Name	Insulin
Hormone Name	Relaxin B chain
Mature Hormone Sequence	RPNWEERSRLCGRDLIRAFIYLCGGTRWTRLPNFGNYPIM
Position of mature hormone in Pre-Hormone protein	40 Residues from position (1-40)
Receptor	N/A
Gene ID	N/A
PDB ID	N/A
Drugpedia	wiki
Comments	!Receptor for this Hormone are either unknown or have not yet been curated

Search Result - 15

HMRbase accession number	11225
Swiss-prot Accession number	P11953 (Sequence in FASTA format)
Description	Relaxin [Contains: Relaxin B chain; Relaxin A chain].
Source organism	Squalus acanthias (Spiny dogfish)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;Elasmobranchii; Squalea; Hypnosqualea; Squaliformes; Squaloidei;Squalidae; Squalus.
Subcellular location	Secreted
Developmental Stage	N/A
Similarity	Belongs to the insulin family.
Tissue Specificity	N/A
Post translational modification	N/A
Function	The function of relaxin in an oviparous species is not yet known
Protein Length	54 Amino acids
Molecular weight	5910
References	1  PubMed abstract 3780747
Domain Name	Insulin
Hormone Name	Relaxin B chain
Mature Hormone Sequence	QSFKNAEPGIKLCGREFIRAVIYTCGGSRW
Position of mature hormone in Pre-Hormone protein	30 Residues from position (1-30)
Receptor	N/A
Gene ID	N/A
PDB ID	N/A
Drugpedia	wiki
Comments	!Receptor for this Hormone are either unknown or have not yet been curated

Search Result - 16

HMRbase accession number	11362
Swiss-prot Accession number	P04090 (Sequence in FASTA format)
Description	Prorelaxin H2 precursor [Contains: Relaxin B chain; Relaxin A chain].
Source organism	Homo sapiens (Human)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular location	Secreted
Developmental Stage	N/A
Similarity	Belongs to the insulin family.
Tissue Specificity	Isoform 1 expressed in the ovary during pregnancy. Also expressed in placenta, decidua and prostate. Isoform 2 relatively abundant in placenta, much lower abundance in the prostate gland. Not detected in the ovary
Post translational modification	N/A
Function	Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix
Protein Length	185 Amino acids
Molecular weight	21043
References	1  PubMed abstract 6548702 2  PubMed abstract 15164053 3  PubMed abstract 15489334 4  PubMed abstract 8735594 5  PubMed abstract 10601981 6  PubMed abstract 1572287 7  PubMed abstract 2076464 8  PubMed abstract 2040595 9  PubMed abstract 1656049
Domain Name	Insulin
Hormone Name	Relaxin B chain
Mature Hormone Sequence	DSWMEEVIKLCGRELVRAQIAICGMSTWS
Position of mature hormone in Pre-Hormone protein	29 Residues from position (25-53)
Receptor	Q9HBX9   Detail in HMRbase    Q8WXD0    Detail in HMRbase
Gene ID	6019
PDB ID	6RLX
Drugpedia	wiki
Comments

Search Result - 17

HMRbase accession number	11369
Swiss-prot Accession number	P04808 (Sequence in FASTA format)
Description	Prorelaxin H1 precursor [Contains: Relaxin B chain; Relaxin A chain].
Source organism	Homo sapiens (Human)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular location	Secreted
Developmental Stage	N/A
Similarity	Belongs to the insulin family.
Tissue Specificity	Prostate. Not expressed in placenta, decidua or ovary
Post translational modification	N/A
Function	Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix
Protein Length	185 Amino acids
Molecular weight	21146
References	1  PubMed abstract 6548702 2  PubMed abstract 6298628 3  PubMed abstract 15164053 4  PubMed abstract 15489334 5  PubMed abstract 8735594 6  PubMed abstract 10601981
Domain Name	Insulin
Hormone Name	Relaxin B chain
Mature Hormone Sequence	VAAKWKDDVIKLCGRELVRAQIAICGMSTWS
Position of mature hormone in Pre-Hormone protein	31 Residues from position (23-53)
Receptor	Q9HBX9   Detail in HMRbase    Q8WXD0    Detail in HMRbase
Gene ID	6013
PDB ID	N/A
Drugpedia	wiki
Comments